| Clinical Reviews and Opinions |
Dear Colleague,
We received a manuscript titled:Gastrointestinal Stromal Tumor: the promise of gene therapy coupled with traditional surgical resection.
The Abstract is given below:
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors arising from the interstitial cells of Cajal. Originally thought to be leiomyosarcomas, these tumors are traditionally resistant to chemotherapy and radiation therapy. Molecular studies have identified the gene mutations that cause these masses to proliferate. The KIT proto-oncogene and PDGFRA mutations have been successfully implicated as the insults leading to disease. GISTs are diagnosed using both pathology and radiology. Immunohistochemistry provides the definitive diagnosis. Radiology is extremely useful in identifying disease and possible metastases. Furthermore the use of PET scans, particularly PET/CT allow clinicians to monitor and tailor therapy. Successful management of GISTs involves medical and surgical therapy. Imatinib mesylate is a drug used to inhibit the product of the KIT proto-oncogene. Coupled with surgery, this combination holds promise in successful management and possible eradication of disease.
(key words)
Gastrointestinal Stromal Tumor, GIST, PET Scan, Imatinib, Gene Therapy, Small Bowl Obstruction
I wish to inquire if you can create time to review this manuscript. We will be most grateful if the manuscript can be reviewed and sent to us within 2 weeks. Please kindly send us your response within 72hours from now.
I am looking forward to your response.
Best regards,
Aghuniafe Onajite
Editorial Assistant
Clinical Reviews and Opinions (CRO)
E-mail: cro.journal@gmail.com or cro.acadjourn@gmail.com
http://www.academicjournals.org/cro
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